Technology

Testing Technology

We are conducting reseach on analyzing trace compounds in exhaled human breath and bodily fluids for use in early disease detection and preventive medicine.
We have developed an innovative testing method that enables high-precision measurement and analysis of biomarkers such as volatile organic compounds (VOCs), allowing for rapid and non-invasive disease risk assessment.

Method of Measuring Volatile Organic Compounds (VOCs)

  1. Step 1

    Breath Collection

    Collect breath from patients at medical institutions and transfer it to a collection tube suitable for analysis.

  2. Step 2

    Analysis by Device

    Measure breath components using a thermal desorption system/gas chromatography mass spectrometry (TD/GC–MS).

  3. Step 3

    Data Analysis

    Analyze the information obtained from the analysis results to evaluate and analyze the characteristic breath patterns and trends for each participant.

By analyzing breath data using machine learning and AI,
we can identify differences in breath patterns between healthy individuals and patients,allowing for more accurate and early diagnosis of diseases.

Number of VOCs

Studies have revealed that breath contains 874 different VOCs, far exceeding the number found in other samples such as skin, stool, saliva, urine, and blood.This characteristic represents a significant advantage for early disease detection using breath-based testing.

Number of VOCs
呼気、皮膚、糞便、唾液、尿、血液の各生体サンプルに含まれるVOCsの種類数を比較した棒グラフ。呼気が874種類で最も多く、皮膚504種類、糞便381種類、唾液353種類、尿279種類、血液130種類の順に少なくなる。青い棒は各サンプルのVOCs総数、緑色の棒は呼気と共通するVOCs数を示している

Advantages of
Breath Testing

Non-invasive
Painless
No radiation exposure
High Precision
Sensitivity: 91.6%
Specificity 89.3%(analyzed using ALG and AI)
Convenience
Testing can be performed anywhere
Dry sample
Designed for easy transportation via standard logistics

Equipment Used
for Testing

VOCs collection device

GC/MS: Instrument used to analyze volatile compounds

How the Test Works

  1. 1

    VOCs Collection

    Collect VOCs from exhaled breath using specially designed collection kit collection

  2. 2

    Analysis Process

    Detailed analysis of breath components using GC/MS (Gas Chromatography Mass Spectrometry)

  3. 3

    Breast Cancer Marker Detection

    Identifying breast cancer-specific biomarkers from among approximately 5,000 types of VOCs

  4. 4

    AI Analysis

    Our proprietary algorithm, integrated with AI, compares the waveform data between healthy individuals and breast cancer patients

  5. 5

    Diagnostic Evaluation

    Highly accurate assessment of breast cancer possibility (Capable of detecting from Stage 0)

Test Procedure

Our breath contains 80% nitrogen, 16% oxygen, and 4% carbon dioxide among other gases. In addition, it contains trace amounts of approximately 5,000 different VOCs.Our company detects cancer-related volatile organic compounds (VOCs) from among various VOCs using gas chromatography mass spectrometry (GC/MS). Based on breast cancer biomarkers identified by university research in Isreal, waveform analysis is performed using our proprietary algorithms and AI.

  1. Step1

    Breath Collection

    Breath is blown into a specialized device

  2. Step2

    Breath Analysis

    Collected breath is analyzed using analytical instrument

  3. Step3

    Data Analysis

    Waveform analysis performed using proprietary algorithms and AI

  4. Step4

    Diagnostic Evaluation

    Determining the possibility of breast cancer